NovaBone® Dental Bone Putty – Synthetic CPS Bone Graft

NovaBone® Dental Bone Putty is a 100% synthetic, fully resorbable calcium phosphosilicate (CPS) bone graft in a moldable putty form. It simplifies graft handling and delivery while providing a stable, osteostimulative and osteoconductive scaffold for predictable bone regeneration.

Key Features

• 100% synthetic and resorbable calcium phosphosilicate (CPS) dental bone putty
• Osteostimulative and osteoconductive for predictable bone regeneration
• More than 20 years of international clinical use with 50+ studies on file
• Pre-mixed, cohesive, moldable, and easily adaptable to defect morphology
• Stable at room temperature — no refrigeration required
• 4-year shelf life for flexible inventory management
• Appears partially opaque on radiographs for visual confirmation of graft placement

Three Convenient Delivery Options

NovaBone® Dental Bone Putty is available in three delivery formats to match clinician preference and clinical access:

• Uni-dose Syringe
  Enables precise, controlled delivery with full visualization of the graft quantity being used.
• Uni-dose Cartridges
  Designed for use with a cartridge delivery system, simplifying handling and delivery into confined or hard-to-reach surgical sites.
• Tray Dose (Hand-Moldable Putty)
  Designed for manual handling — the clinician kneads and shapes the material (using sterile gloves after opening) for precise adaptation and press-fit into defects.

Unique Formulation

NovaBone® Dental Putty combines CPS particles in a bimodal size distribution with a polyethylene glycol and glycerine binder. Approximately 70% of the putty volume consists of bioactive CPS.

• The water-soluble binder is absorbed within 24–72 hours after implantation.
• Binder resorption creates a 3D porous scaffold that facilitates blood and fluid diffusion through the matrix.
• Smaller CPS particles (32–125 μm) resorb faster, providing an initial release of calcium and phosphate ions.
• Larger CPS particles (90–710 μm) resorb more slowly, supporting sustained bone regeneration.

Osteostimulative & Osteoconductive Action

Unlike most synthetic grafts that are only osteoconductive, NovaBone® is both osteoconductive and osteostimulative. After implantation:

• Controlled surface reactions release Si, Ca, and P ions
• Absorption of the graft material occurs concurrently with new bone formation
• Osteoblast proliferation is stimulated in vitro, with increased DNA, osteocalcin, and alkaline phosphatase expression
• Gene array studies confirm upregulation of osteogenic gene families in vitro

Handling Characteristics

NovaBone® Dental Putty is engineered for efficiency and simplicity:

• Ready to use — no mixing or preparation required
• Pre-mixed and cohesive to minimize particulate scatter
• Moldable, stable, and easily shaped to match defect contours
• Maintains space between particles to support revascularization and bone ingrowth
• Stable at room temperature, 4-year shelf life, and partially opaque under X-ray

Clinical Insight

Preferred by many Densah® users for sinus lift "bump" procedures and other applications where moldable, radiovisible synthetic graft material is required.